Change the world

Research Chair in Microfluidic Bio/Chemical Processing

Peer reviewed publications: 

2016

  • A Facile Optimization of Diazotization and Phase Transfer Catalyzed Azo Coupling Reactions in Microreactors, F. M. Akwi, C. Bosma and P. Watts, J. Flow Chem., 2016, 6, 73-79.
  • Synthesis routes to anti-HIV drugs, D. Mandala, W.A. Thompson and P. Watts, Tetrahedron, 2016, 72, 3389-3420.
  • Disproportionation of triethoxysilane over anion exchange resins, F. Chigondo and P. Watts, Catalysis Lett., 2016, 146, 1445-1448.
  • The in situ generation and reactive quench of diazonium compounds in the synthesis of azo compounds in microreactors, F. M. Akwi and P. Watts, Beilstein J.Org. Chem., 2016, 12, 1987-2004.
  • Solvent free synthesis of novel para-menthane-3,8-diol ester derivatives from citronellal using polymer supported scandium triflate catalyst, L. Mafu, B. Zeelie and P. Watts, Beilstein J.Org. Chem., 2016, 12, 2046-2054.
  • A study on the scale-up of phase transfer catalyzed azo coupling reactions in flow reactors leading to heterocyclic molecules, F. M. Akwi and P. Watts, Chemistry of Heterocyclic Compounds, 2016, in press.
  • Selective Direct Synthesis of Trialkoxysilanes in a Packed Bed Flow Tubular Reactor, F. Chigondo, B. Zeelie and P. Watts, ACS Sustainable Chem. Eng., 2016, 4, 6237-6243.

 

      2015

  • Doping of Inorganic Materials in Microreactors - Preparation of Zn doped Fe3O4 Nanoparticles, M. D. Simmons, N. Jones, D. J. Evans, C. Wiles, P. Watts, S. Salamon, M. Escobar Castillo, H. Wende, D. Lupascu and M. G. Francesconi, Lab on a Chip, 2015, 15, 3154-3162.
  • Continuous flow reactor technology for nanomaterial synthesis, P. Watts, J Biochips Tissue Chips, 2015, 5(1), 1-3.

 

2014

  • Continuous Process Technology: A Tool for Sustainable Production, C. Wiles and P. Watts, Green Chem., 2014, 16, 55-62.

 

2013

  • Purification of 2-[18F]fluoro-2-deoxy-D-glucose by on-chip solid-phase extraction, M. D. Tarn, G. Pascali, F. De Leonardis, P. A. Salvadori, P. Watts and N. Pamme, Journal of Chromatography A, 2013, 1280, 117-121.
  • Sol-gel catalysts an efficient tool for the Kumada-Corriu reaction in continuous flow, L. Marra, V. Fusillo, C. Wiles, A. Zizzari, P. Watts, R. Rinaldi and V. Arima, Sci. Adv. Mater., 2013, 5, 475-483.
  • Synthesis of magnetic iron oxide nanoparticles in microreactors, M. Simmons, C. Wiles, V. Rocher, M. G. Francesconi and P. Watts, J. Flow Chem., 2013, 3, 7-10.
  • Microfluidics in radiopharmaceutical chemistry, G. Pascali, P. Watts and P. A. Salvadori, Nuclear Medicine and Biology, 2013, 40(6), 776-787.
  • Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals, V. Arima, G. Pascali, O. Lade, H. R. Kretschmer,  I. Bernsdorf,  V. Hammond,  P. Watts,  F. De Leonardis, M. D. Tarn, N. Pamme,  B. Z. Cvetkovic,  P. S. Dittrich, N. Vasovic,  R. Duane,  A. Jaksic,  A. Zacheo,  A. Zizzari,  L. Marra, E. Perrone, P. A. Salvadori and  R. Rinaldi, Lab on a Chip, 2013, 13, 2328-2336.

 

2012

  • Continuous flow reactors: A green chemistry perspective, C. Wiles and P. Watts, Green Chem., 2012, 14, 38-54.
  • Solid-supported gallium triflate: An efficient catalyst for the three-component ketonic Strecker reaction, C. Wiles and P. Watts, ChemSusChem., 2012, 5, 332-338.
  • Micro reactors, flow reactors and continuous flow synthesis, P. Watts, J. Chem. Res., 2012, 181-193.
  • Positron emission tomography radiosynthesis in microreactors, P. Watts, G. Pascali and P. A. Salvadori, J. Flow Chem., 2012, 2, 37-42.

 

2011

  • Improved method for kinetic studies in micro reactors using flow manipulation and noninvasive Raman spectrometry, S. Mozharov, A. Nordon, D. Littlejohn, C. Wiles, P. Watts, P. Dallin and J. M. Girkin, J. Am. Chem. Soc., 2011, 133, 3601-3608.
  • Recent advances in synthetic micro reaction technology, C. Wiles and P. Watts, Chem. Commun., 2011, 47, 6512-6535.
  • On-chip pre-concentration and complexation of [18F]fluoride ions via regenerable anion exchange particles for radiochemical synthesis of Positron Emission Tomography tracers, F. De Leonardis, G. Pascali, P. A. Salvadori, P. Watts and N. Pamme, Journal of Chromatography A, 2011, 1218, 4714-4719.
  • Translation of microwave methodology to continuous flow for the synthesis of diaryl ethers via an SNAr Reaction, C. Wiles and P. Watts, Beilstein Journal of Organic Chemistry, 2011, 7, 1360-1371.

 

2010

  • The development and evaluation of a conducting matrix for the electrochemical regeneration of the immobilised co-factor NAD(H) under continuous flow,  B. Ngamsom, A. M. Hickey, G. M. Greenway, J. A. Littlechild, T. McCreedy, P. Watts and C. Wiles, Org. Biomol. Chem., 2010, 8, 2419-2424.
  • Synthesis of Substitued Indoles Using Continuous Flow Micro Reactors, B. Wahab, G. Ellames, S. Passey and P. Watts, Tetrahedron, 2010, 66, 3861-3865.
  • Three-dimensional Mach-Zehnder interferometer in a microfluidic chip for spatially-resolved label-free detection, A. Crespi, Y. Gu, B. Ngamsom, H.J.W.M. Hoekstra, C. Dongre, M. Pollnau, R. Ramponi, H. H. van den Vlekkert, P. Watts, G. Cerullo and R. Osellame, Lab on a Chip, 2010, 10, 1167-1173.
  • Development of a high throughput screening tool for biotransformations utilising a thermophilic L-aminoacylase enzyme, B. Ngamsom, A. M. Hickey, G. M. Greenway, J. A. Littlechild, P. Watts and C. Wiles, Journal of Molecular Catalysis B: Enzymatic, 2010, 63, 81-86.
  • The Scale-Up of Organic Synthesis using Micro Reactors, C. Wiles and P. Watts, Chemica  Oggi, 2010, 28(3), 3-5.

 

2009

  • The use of immobilised crown ethers as in situ N-protecting groups in organic synthesis and their application under continuous flow, G. P. Wild, C. Wiles, P. Watts and S. J. Haswell, Tetrahedron, 2009, 65, 1618-1629.
  • Enhanced Chemical Synthesis in Flow Reactors, C. Wiles and P. Watts, Chemica  Oggi, 2009, 27(3), 34-36.
  • The development and evaluation of a continuous flow process for the lipase mediated oxidation of alkenes, C. Wiles, M. J. Hammond and P. Watts, Beilstein Journal of Organic Chemistry, 2009, 5(27), 1-12.
  • Microreactors as tools for high-throughput synthesis, C. Wiles and P. Watts, Speciality Chemicals Magazine, 2009, 40-41.
  • Continuous flow organic synthesis, a tool for the modern medicinal chemistry, C. Wiles and P. Watts, Future Medicinal Chemistry, 2009, 1593-1612.    
  • A micro reactor for the study of biotransformations by a cross-linked gamma-lactamase enzyme, A. M. Hickey, B. Ngamsom, C. Wiles, G. M. Greenway, P. Watts and J. A. Littlechild, Biotechnology J., 2009, 4(4), 510-516.

 

2008

  • An optical sensor for reactive oxygen species: Encapsulation of functionalised silica nanoparticles into silicate nanoprobes to reduce fluorophore leaching, V. J. Hammond, J. W. Aylott, G. M. Greenway, P. Watts, A. Webster and C. Wiles, The Analyst, 2008, 133, 71-75.
  • Improving organic reactions using flow reactors, C. Wiles and P. Watts, Eur. J. Org. Chem., 2008, 1655-1671.
  • N-N Bond cleavage in N-Nitrosoarylamines, L. A. Evans, M. Petrovic, M. Antonijevic, C. Wiles, P. Watts and J. Wadhawan, J. Phys. Chem. C, 2008, 112, 12928-12935.
  • An integrated microreactor for the multicomponent synthesis of a-aminonitriles, C. Wiles and P. Watts, OPRD, 2008, 12, 1001-1006.
  • Deuterated Isotope Labelling of Phenol Derivatives within Micro Reactors, J. Hooper, P. Watts and C. Wiles, Microfluidics and Nanofluidics, 2008, 5, 595-602.
  • Evaluation of the heterogeneously catalysed strecker reaction conducted under continuous flow, C. Wiles and P. Watts, Eur. J. Org. Chem., 2008, 5597-5613.
  • Enzymatic synthesis of a series of alkyl esters using Novozyme 435 in a packed-bed, miniaturized, continuous flow reactor, L. L. Woodcock, C. Wiles, G. M. Greenway, P. Watts, A. Wells and S. Eyley, Biocatalysis and Biotransformation, 2008, 26, 501-507.

 

2007

  • Electrosynthesis of phenyl-2-propanone derivatives from benzyl bromides and acetic anhydride in an unsupported micro-flow cell electrolysis process, P. He, P. Watts, S. J. Haswell and F. Marken, Green Chem, 2007, 9, 20-22.
  • Scaling out of electrolyte free electrosynthesis in a micro-gap flow cell, P. He, F. Marken, S.J. Haswell and P. Watts, Lab Chip, 2007, 7, 141-143.
  • Recent advances in synthetic micro reaction technology, C. Wiles and P. Watts, Chem. Commun., 2007, 443-467.
  • The use of electroosmotic flow as a pumping mechanism for semi-preparative scale continuous flow synthesis, C. Wiles, P. Watts and S. J. Haswell, Chem. Commun., 2007, 966-968.
  • Micro Reactors: A New Tool for the Synthetic Chemist, C. Wiles and P. Watts, Org. Bio. Chem., 2007, 5, 727-732.
  • Synthesis of analytically pure compounds in flow reactors, C. Wiles and P. Watts, Chem. Eng. Technol., 2007, 30, 329-333.
  • The use of solid-supported reagents for the multi-step synthesis of a combinatorial array of analytically pure a,b-unsaturated compounds in miniaturized flow reactors, C. Wiles, P. Watts and S. J. Haswell, Lab Chip, 2007, 7, 322-330.
  • The Synthesis of Deuterium Labelled Amides within Micro Reactors, J. Hooper and P. Watts, J. Label. Compd. Radiopharm, 2007, 50, 189-196.
  • Separation of [18F]fluoride ion from proton-irradiated [18O]water within an EOF-driven micro-reactor, S. Lu, M. J. Gilde, A. Prak, P. Watts and V. Pike, J. Label. Compd. Radiopharm, 2007, 50, 597-599.
  • An expedient, scalable synthesis of the natural product L-anserine, C. Wiles and P. Watts, Synthesis., 2007, 2608-2610.
  • An efficient, continuous flow technique for the chemoselective synthesis of thioacetals, C. Wiles, P. Watts and S. J. Haswell, Tetrahedron Lett., 2007, 48, 7362-7365.
  • Immobilisation of thermophilic enzymes in miniaturised flow reactors, A. M. Hickey, L. Marle, T. McCreedy, P. Watts, G. M. Greenway and J. A. Littlechild, Biochemical Society Transactions, 2007, 35, 1621-1623.
  • Improving Chemical Synthesis Using Flow Reactors, C. Wiles and P. Watts, Expert Opinion on Drug Discovery, 2007, 2, 1487-1503.
  • Parallel synthesis in an EOF-based micro reactor, C. Wiles and P. Watts, Chem. Commun., 2007, 4928-4930.

 

2006

  • Solid supported chemiluminescence and electrogenerated chemiluminescence based on a tris(2,2’-bipyridyl)ruthenium (II) derivative, G. M. Greenway, A. Greenwood, P. Watts and C. Wiles, Chem. Commun., 2006, 85-87.
  • Towards paired and coupled electrode reactions for clean organic micro reactor electrosynthesis, C. A. Paddon, M. Atobe, T. Fuchigami, P. He, P. Watts, S. J. Haswell, G. J. Pritchard, S. D. Bull and F. Marken, Journal of Applied Electrochemistry, 2006, 36, 617-634.
  • Flow reactors for organic synthesis, G. P. Wild, C. Wiles and P. Watts, Letters in Organic Chemistry, 2006, 3, 419-425.
  • Microreactor as tools for chemical research, X. Zhang, C. Wiles, S. L. Painter, P. Watts and S. J. Haswell, Chimica Oggi, 2006, 24, 43-45.
  • Efficient protein digestion with peptide separation in a micro device interfaced to electrospray mass spectrometry, H. Al-Lawati, P. Watts and K. J. Welham, Analyst, 2006, 131, 656-663.
  • Clean and selective oxidation of aromatic alcohols using silica-supported Jones reagent in a pressure-driven flow reactor, C. Wiles, P. Watts and S. J. Haswell, Tetrahedron Lett., 2006, 47, 5261-5264.
  • Self-Supported and Clean One-Step Cathodic Coupling of Activated Olefins with Benzylbromide Derivatives in a Micro Flow Reactor, P. He, F. Marken, S.J. Haswell and P. Watts, Angew. Chemie., Int. Ed. Eng., 2006, 45, 4146-4149.
  • The application of micro reactors for radiochemical synthesis, P. Watts, J. Label. Compd. Radiopharm, 2006, 49, 395-396.
  • Isotopic labelling within micro reactors, J. Hooper, P. Watts and C. Wiles, J. Label. Compd. Radiopharm, 2006, 49, 417-418.
  • The use of solid supported reagents in continuous flow reactors, C. Wiles, P. Watts and S. J. Haswell, J. Label. Compd. Radiopharm, 2006, 49, 419-420.

 

2005

  • The application of micro reactors for organic synthesis, P. Watts and S. J. Haswell, Chem. Soc. Rev., 2005, 34, 235-246.
  • Assembly intermediates in polyketide biosynthesis: enantioselective synthesis of b-hydroxycarbonyl compounds, C. Le Sann, D. M. Munoz, N. Saunders, T. J. Simpson, D. I. Smith, F. Soulas, P. Watts and C. L. Willis, Org. Biomol. Chem., 2005, 3, 1710-1728.
  • Acid catalysed synthesis and deprotection of dimethyl acetals in a miniaturised electroosmotic flow reactor, C. Wiles, P. Watts and S. J. Haswell, Tetrahedron, 2005, 61, 5209-5217.
  • The application of micro reactors for small scale organic synthesis, P. Watts and S. J. Haswell, Chem. Eng. Technol., 2005, 28, 290-301.
  • Microreactors for drug discovery: the importance of integrating chemical synthesis with real-time analytical detection, P. Watts, Anal. Bioanal. Chem., 2005, 382, 865-867.
  • Electrolyte free electroorganic synthesis: The cathodic dimerisation of 4-nitrobenzylbromide in a micro-gap flow cell, P. He, P. Watts, S. J. Haswell and F. Marken, Electrochemistry Communications, 2005, 7, 918-924.
  • The preparation and reaction of carbanions within micro reactors, C. Wiles, P. Watts, S. J. Haswell and E. Pombo-Villar, Tetrahedron, 2005, 61, 10757-10773.
  • The use of solid supported reagents in continuous flow reactors, C. Wiles, P. Watts and S. J. Haswell in Micro Total Analysis Systems (mTAS) 2005 edited by T. Laurell, J. Nilsson, K. Jensen, D. J. Harrison and J. P. Kutter, TRF, 2005, 1437-1439.
  • Combinatorial synthesis in micro reactors, P. Watts, QSAR and Combinatorial Science, 2005, 24, 701-711.

 

2004

  • The application of microreactor technology for the synthesis of 1,2-azoles, C. Wiles, P. Watts, S. J. Haswell and E. Pombo-Villar, OPRD, 2004, 8, 28-32.
  • Organic Synthesis in Micro Reactors, X. Feng, S. J. Haswell and P. Watts, Current Topics in Medicinal Chemistry, 2004, 4, 707-727.
  • Chemical synthesis in lab-on-a-chip micro reactors, P. D. I. Fletcher, S. J. Haswell, P. Watts and X. Zhang in Encyclopedia of nanoscience edited by J. A. Schwarz, C. I. Contescu and K. Putyera, Dekker, 2004, volume 2, 1547-1564.
  • Benchmarking micro reactor applications, H. Pennemann, P. Watts, S. J. Haswell, V. Hessel and H. Lowe, OPRD, 2004, 8, 422-439.
  • Stereoselective alkylation of an Evans auxiliary derivative within a pressure driven micro reactor, C. Wiles, P. Watts, S. J. Haswell and E. Pombo-Villar, Lab Chip, 2004, 4, 171-173.
  • Electrochemical effects related to synthesis in micro reactors operating under electrokinetic flow, P. Watts, S. J. Haswell and E. Pombo-Villar, Chemical Engineering Journal, 2004, 101, 237-240.
  • Chemical Synthesis in micro reactors, P. Watts, Chemie Ingenieur Technik, 2004, 76, 555-559.
  • An investigation into the use of silica supported bases within EOF based flow reactors, C. Wiles, P. Watts and S. J. Haswell, Tetrahedron, 2004, 60, 8421-8427.
  • Combinatorial synthesis in micro reactors, P. Watts and S. J. Haswell, Combinatorial Chemistry and High Throughput Screening, 2004, 7, 397-405.
  • Solid supported continuous flow synthesis in micro reactors using electroosmotic flow, N. Nikbin and P. Watts, OPRD, 2004, 8, 942-944.
  • Synthesis of 11C- and 18F-labeled carboxylic esters within a hydrodynamically driven micro reactor, S. Lu, P. Watts, F. T. Chin, J. Hong, J. L. Musachio, E. Briard and V. W. Pike, Lab Chip, 2004, 4, 523.
  • Continuous flow micro reactors for drug discovery, P. Watts, Current Opinion in Drug Discovery and Development, 2004, 807.
  • Exploration of a micro reactor for the synthesis of non carrier added 11C- and 18F-labelled carboxylic esters, S. Lu, P. Watts, F. T. Chin, J. Hong, J. L. Musachio, E. Briard and V. W. Pike, European Journal of Nuclear Medicine and Molecular Imaging, 2004, 31, 248.
  • The use of solid supported reagents within EOF-based micro reactors, C. Wiles, P. Watts and S. J. Haswell in Micro Total Analysis Systems (mTAS) 2004 edited by T. Laurell, J. Nilsson, K. Jensen, D. J. Harrison and J. P. Kutter, RSC, 2004, 105-107.

 

2003

  • On-chip separation of peptides prepared within a micro reactor, V. George, P. Watts, S. J. Haswell and E. Pombo-Villar, Chem. Commun., 2003, 2886-2887.
  • Solution phase synthesis of esters within a micro reactor, C. Wiles, P. Watts, S. J. Haswell and E. Pombo-Villar, Tetrahedron, 2003, 59, 10173-10179.
  • Continuous flow reactors for drug discovery, P. Watts and S. J. Haswell, Drug Discovery Today, 2003, 8, 586-593.
  • Microfluidic combinatorial chemistry, P. Watts and S. J. Haswell, Current Opinion in Chemical Biology, 2003, 7, 380-387.
  • Solution phase synthesis of peptides in micro reactors, P. Watts, Biopolymers, 2003, 71, 347.
  • Green Chemistry: Synthesis in Micro Reactors, P. Watts and S. J. Haswell, Green Chemistry, 2003, 5, 240-249.

 

2002

  • The regioselective preparation of 1,3-diketones, C. Wiles, P. Watts, S. J. Haswell and E. Pombo-Villar, Tetrahedron Lett., 2002, 43, 2945-2948.
  • The regioselective preparation of 1,3-diketones in a micro reactor, C. Wiles, P. Watts, S. J. Haswell and E. Pombo-Villar, Chem. Commun., 2002, 1034-1035.
  • 1,4-Addition of enolates to a,b-unsaturated ketones within a micro reactor, C. Wiles, P. Watts, S. J. Haswell and E. Pombo-Villar, Lab on a Chip, 2002, 2, 62-64.
  • Micro reactors: principles and applications in organic synthesis, P. D. I. Fletcher, S. J. Haswell, E. Pombo-Villar, B. H. Warrington, P. Watts, S. Y. F. Wong and X. Zhang, Tetrahedron, 2002, 58, 4735-4757.
  • Solution phase synthesis of b-peptides using micro reactors, P. Watts, C. Wiles, S. J. Haswell and E. Pombo-Villar, Tetrahedron, 2002, 58, 5427-5439.
  • Investigation of racemisation in peptide synthesis within a micro reactor, P. Watts, C. Wiles, S. J. Haswell and E. Pombo-Villar, Lab on a Chip, 2002, 2, 141-144.

 

2001

  • The application of micro reactors to synthetic chemistry, S. J. Haswell, R. J. Middleton, B. O’Sullivan, V. Skelton, P. Watts and P. Styring, Chem. Commun., 2001, 391-398.
  • The synthesis of peptides in micro reactors, P. Watts, C. Wiles, S. J. Haswell, E. Pombo-Villar and P. Styring, Chem. Commun., 2001, 990-991.
  • The aldol reaction of silyl enol ethers within a micro reactor, C. Wiles, P. Watts, S. J. Haswell and E. Pombo-Villar, Lab on a Chip, 2001, 1, 100-101.
  • The synthesis of peptides using micro reactors, P. Watts, C. Wiles, S. J. Haswell, E. Pombo-Villar and P. Styring in Microreaction technology IMRET 5: Proceedings of the fifth international conference on microreaction technology edited by M. Matlosz, W. Ehrfeld and J. P. Baselt, 2001, 508-517.

 

1999

  • A general synthesis of homochiral b-hydroxy N-acetylcysteamine thioesters, C. Le Sann, T. J. Simpson, D. I. Smith, P. Watts and C. L. Willis, Tetrahedron Lett., 1999, 40, 4093-4096.